According to the Centers for Disease Control and Prevention, the prevalence of use of e-cigs increased 9-fold—from 1.5% to 13.4%—among high school students between 2011 and 2014, and now exceeds the use of conventional cigarettes (9.2%).6 Aside from the unknown lifetime trajectory of tobacco use among young people who adopt e-cig use, we are only beginning to understand the lifelong effects of nicotine on the developing brains of teenagers, which includes altered development of the cerebral cortex and hippocampus.*